Name | m-Hydroxyacetophenone |
Synonyms | m-Acetylphenol 3-Hydroxyacetophenon m-Hydroxyacetophenone m-Hydroxyacetophenonel META-HYDROXYACETOPHENONE Ethanone, 1-(3-hydroxyphenyl)- 3'-Hydroxyacetophenone 3-Acetylphenol m-Acetylphenol |
CAS | 121-71-1 |
EINECS | 204-494-0 |
InChI | InChI=1/C8H8O2/c1-6(9)7-3-2-4-8(10)5-7/h2-5,10H,1H3 |
Molecular Formula | C8H8O2 |
Molar Mass | 136.15 |
Density | 1.1 |
Melting Point | 94-97℃ |
Boling Point | 296℃ |
Flash Point | 296°C |
Water Solubility | Soluble in alcohol. Insoluble in water. |
Appearance | White crystal |
Storage Condition | Room Temprature |
MDL | MFCD00002298 |
Physical and Chemical Properties | Density 1.10 melting point 94-97°C boiling point 296°C |
Use | Used in organic synthesis, is also an intermediate of the drug Phenylephrine |
Hazard Symbols | Xi - Irritant |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 3 |
Hazard Note | Harmful/Irritant |
TSCA | Yes |
customs code | 29143990 |
storage conditions | Inert atmosphere,Room Temperature |
solubility | 22g/l |
acidity coefficient (pKa) | 9.19(at 25℃) |
morphology | Crystalline Powder |
color | Beige-brown |
water solubility | Soluble in alcohol. Insoluble in water. |
BRN | 2040676 |
InChIKey | LUJMEECXHPYQOF-UHFFFAOYSA-N |
NIST chemical information | Ethanone, 1-(3-hydroxyphenyl)-(121-71-1) |
EPA chemical information | Ethanone, 1-(3-hydroxyphenyl)- (121-71-1) |
It is obtained by the reaction of m-aminoacetophenone and sodium nitrite. Add water and concentrated sulfuric acid into the reaction pot, add m-aminoacetophenone under stirring, and then add sodium nitrite aqueous solution dropwise under cooling, keep the temperature at 8-10 ℃, slowly raise the temperature to above 90 ℃ after adding, and continue stirring for 1h. The solid is precipitated by cooling, filtered, and the obtained crude product is recrystallized with hot water to obtain m-hydroxyacetophenone. 65% yield.